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Cell Reports published the latest research of Prof. Cheguo Cai's team as cover article
?On Sep 13 2022, a research team led by Prof. CAl Cheguo, Medical Research Institute and Frontier Science Center for lmmunology and Metabolism of Wuhan University, just made progress in mammary stem cell (MaSC) and triple negative breast cancer (TNBC) research.Their work, “CDK14 inhibition reduces mammary stem cell activity and suppresses triple negative breast cancer progression”, published...
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New study from Prof. Haojian Zhang's laboratory reveals an important role of YBX1 in acute myeloid leukemia
?On March 24, 2021, the international renowned journal BLOOD published an article entitled "YBX1 is required for maintaining myeloid leukemia cell survival by regulating BCL2 stability in an m6A-dependent manner", reported the molecular mechanism of YBX1 in selectively regulating the survival of myeloid leukemia cells. This work came from Dr. Haojian Zhang’s laboratory. Dr. Zhang is a profess...
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?Li, Y., Zhou, X., Cheng, C., Ding, G., Zhao, P., Tan, K., Chen, L., Perrimon, N., Veenstra, J. A., Zhang, L., & Song, W.* (2023). Gut AstA mediates sleep deprivation-induced energy wasting in Drosophila. Cell discov, 9(1), 49.（宋威）?AbstractSevere sleep deprivation (SD) has been highly associated with systemic energy wasting, such as lipid loss and glycogen depletion. Despite immune dysregu...
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?Xiao, X., Shi, J., He, C., Bu, X., Sun, Y., Gao, M., …, Xie, C.H.*, Zhang, J.* (2023). ERK and USP5 govern PD-1 homeostasis via deubiquitination to modulate tumor immunotherapy. Nat Commun 14, 2859.（张金方）?AbstractThe programmed cell death protein 1 (PD-1) is an inhibitory receptor on T cells and plays an important role in promoting cancer immune evasion. While ubiquitin E3 ligases regula...
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?Zhou, Y., Ye, Z., Wei, W., Zhang, M., Huang, F., Li, J.*, and Cai, C.* (2023). Macrophages maintain mammary stem cell activity and mammary homeostasis via TNF-alpha-PI3K-Cdk1/Cyclin B1 axis. NPJ Regen Med 8, 23.（蔡车国）?AbstractAdult stem cell niche is a special environment composed of a variety stromal cells and signals, which cooperatively regulate tissue development and homeostasis. It i...
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Lu, P., Yang, J., Li, M., Wen, S., Zhang, T., Yan, C., Liu, R., Xiao, Y., Wang, X., and Jiang, W.* (2023). A desert lncRNA HIDEN regulates human endoderm differentiation via interacting with IMP1 and stabilizing FZD5 mRNA. Genome Biol 24, 92.（蒋卫）?AbstractBackground: Extensive studies have revealed the function and mechanism of lncRNAs in development and differentiation, but the majority hav...
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Wang, D., Yin, Z., Wang, H., Wang, L., Li, T., Xiao, R., Xie, T., Han, R., Dong, R., Liu, H.*, Liang, K.*, Qing, G.* (2023). The super elongation complex drives transcriptional addiction in MYCN-amplified neuroblastoma. Sci Adv 9, eadf0005.（刘胡丹、卿国良）?AbstractMYCN amplification in neuroblastoma leads to aberrant expression of MYCN oncoprotein, which binds active genes promoting transcrip...
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